2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion

Base Information

• Chemical Name: 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion
• CAS No.: 104291-19-2
• Molecular Formula: C₂₅H₂₆N₄O₃S
• Molecular Weight: 462.572

Synonyms:2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion

Chemical Property of 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion

Chemical Property:

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Technology Process of 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion

There total 4 articles about 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-Amino-4-chlor-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin (104291-20-5) → 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion (104291-19-2)

Guidance literature:

With thiourea; In propan-1-ol; for 1h; Heating;

Reference yield:

2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride (52162-55-7,69256-45-7,61826-14-0) → 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion (104291-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / 30percent KOH, tetrabutylammonium hydrogensulfate / CH₂Cl₂ / 0.17 h

2: 79 percent / thiourea / propan-1-ol / 1 h / Heating

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; thiourea; In propan-1-ol; dichloromethane;

Reference yield:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (84955-31-7) → 2-Amino-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion (104291-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / 30percent KOH, tetrabutylammonium hydrogensulfate / CH₂Cl₂ / 0.17 h

2: 79 percent / thiourea / propan-1-ol / 1 h / Heating

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; thiourea; In propan-1-ol; dichloromethane;

upstream raw materials:

2-Amino-4-chlor-7-<2-desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin

2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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