10.1016/S0040-4039(00)86396-0
The research aims to synthesize the optically active C.1-C.18 segment of Carzinophilin A (CZ), a natural intercalative bisalkylator with notable antitumor antibiotic activity. The purpose of this study is to develop a synthetic route for this segment to further investigate the chemical and physiological properties of Carzinophilin A and its related compounds. The synthesis involves multiple steps, including condensation, cyclization, oxidation, and hydrogenation processes. The study successfully synthesized the key intermediate compound 2, which is equivalent to the C.1-C.18 segment of Carzinophilin A, and confirmed its structure through spectroscopic data. The work concludes with the completion of the C.1-C.18 segment synthesis, and the authors are progressing towards the synthesis of the C.19-C.25 segment.