(S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate

Base Information

Chemical Name:(S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate
CAS No.:1434125-55-9
Molecular Formula:C₃₄H₄₆N₂O₆Si
Molecular Weight:606.835
Hs Code.:

Synonyms:(S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate

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Chemical Property of (S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate

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Technology Process of (S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate

There total 1 articles about (S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 56583-58-5,76985-10-9,58438-04-3
N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine

: 216974-09-3
methyl (2S)-2-amino-3-{4'-[(tert-butyldimethylsilyl)oxy]phenyl}propanoate

: 1434125-55-9
(S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate

Guidance literature:: N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

methyl (2S)-2-amino-3-{4'-[(tert-butyldimethylsilyl)oxy]phenyl}propanoate; With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 1434125-55-9
(S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate

: C₂₉H₃₈N₂O₄Si

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 1434125-55-9
(S)-methyl 2-(((S)-2-((tert-butoxycarbonyl)amino)-3-naphthalen-2-yl)propanamido)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoate

: 1434125-56-0
C₃₉H₅₂N₆O₇Si

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 1 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;