1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate

Base Information

Chemical Name:1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate
CAS No.:1442472-71-0
Molecular Formula:CH₄O₃S*C₂₆H₂₅F₂N₅O₂
Molecular Weight:573.621
Hs Code.:

Synonyms:1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate

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Chemical Property of 1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate

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Technology Process of 1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate

There total 8 articles about 1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1442472-69-6
1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea

: 1442472-71-0
1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate

Guidance literature:: With methanesulfonic acid; In dichloromethane; acetonitrile;

Reference yield:

: 1012880-04-4
ethyl 2-(4-fluoro-2-methyl-5-nitrophenyl)acetate

: 1442472-71-0
1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 2660.18 Torr

2: caesium carbonate / N,N-dimethyl-formamide / 100 °C

3: trifluoroacetic acid / acetic acid / 8 h / 180 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 20 °C

5: methanesulfonic acid / dichloromethane; acetonitrile

With methanesulfonic acid; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 407640-40-8
2-(4-fluoro-2-methylphenyl)acetic acid

: 1442472-71-0
1-(2-fluoro-5-(1-isopropyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-3-(3-fluorophenyl)urea methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid / 0.25 h / -15 - 5 °C

2: sulfuric acid / 2.5 h / 85 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 2660.18 Torr

4: caesium carbonate / N,N-dimethyl-formamide / 100 °C

5: trifluoroacetic acid / acetic acid / 8 h / 180 °C / Inert atmosphere

6: triethylamine / tetrahydrofuran / 20 °C

7: methanesulfonic acid / dichloromethane; acetonitrile

With methanesulfonic acid; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; caesium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;