6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide

Base Information

Chemical Name:6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide
CAS No.:676631-46-2
Molecular Formula:C₁₉H₁₉ClF₃N₃O₂
Molecular Weight:413.827
Hs Code.:

Synonyms:6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide

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Technology Process of 6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide

There total 2 articles about 6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 130290-79-8
4-tetrahydropyranmethylamine

: 585544-23-6
6-chloro-N-cyclohexylmethyl-nicotinamide

: 676631-46-2
6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 61.0%

: 130290-79-8
4-tetrahydropyranmethylamine

: 676627-04-6
6-(3-chloro-phenylamino)-2-trifluoromethyl-nicotinic acid hydrochloride

: 676631-46-2
6-(3-chloro-phenylamino)-N-(tetrahydro-pyran-4-ylmethyl)-2-trifluoromethyl-nicotinamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;