N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

Base Information

• Chemical Name: N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine
• CAS No.: 130985-45-4
• Molecular Formula: C₅₃H₈₁N₉O₈
• Molecular Weight: 972.282

Synonyms:N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

Chemical Property of N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

There total 7 articles about N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-44-3) → N-α--L-phenylalanyl>-Nα-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-45-4)

Guidance literature:

With benzotriazol-1-ol; In methanol; for 18h;

DOI:10.1021/jm00106a026

Reference yield:

ethyl 3-amino-3-methylbutanoate (85532-42-9) → N-α--L-phenylalanyl>-Nα-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-45-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / CH₂Cl₂ / 18 h

2: 82 percent / aq. KOH / tetrahydrofuran / 18 h

3: 100 percent / diisopropylethylamine, diethylphosphorocyanate / CH₂Cl₂ / 18 h

4: 80 percent / 1-hydroxybenzotriazole / methanol / 18 h

With potassium hydroxide; diethyl cyanophosphonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm00106a026

Reference yield:

ethyl 3-methylbut-2-enoate (638-10-8) → N-α--L-phenylalanyl>-Nα-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-45-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / NH₃(gas) / ethanol / 22 h / 80 °C

2: 81 percent / CH₂Cl₂ / 18 h

3: 82 percent / aq. KOH / tetrahydrofuran / 18 h

4: 100 percent / diisopropylethylamine, diethylphosphorocyanate / CH₂Cl₂ / 18 h

5: 80 percent / 1-hydroxybenzotriazole / methanol / 18 h

With potassium hydroxide; diethyl cyanophosphonate; ammonia; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1021/jm00106a026

upstream raw materials:

N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

ethyl 3-methylbut-2-enoate

ethyl 3-amino-3-methylbutanoate

3-[(tert-butoxycarbonyl)amino]-3-methylbutanoic acid

Downstream raw materials:

N-α-(β-L-valyl-L-phenylalanyl)-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine tris(trifluoroacetate)

N-α--L-phenylalanyl>-N^α-methyl-L-histidyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 130985-45-4 N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send