4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole

Base Information

• Chemical Name: 4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole
• CAS No.: 1085337-59-2
• Molecular Formula: C₂₅H₂₈BrNO₂S₃Si
• Molecular Weight: 578.69

Synonyms:4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole

Chemical Property of 4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole

Chemical Property:

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Technology Process of 4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole

There total 1 articles about 4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-bromo-3-(bromomethyl)-1-tosyl-1H-indole (1085337-58-1) + 2-<(trimethylsilyl)ethynyl>-1,3-dithiane (76649-03-1) → 4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole (1085337-59-2)

Guidance literature:

2-<(trimethylsilyl)ethynyl>-1,3-dithiane; With n-butyllithium; In tetrahydrofuran; hexane; at -40 - -20 ℃; for 1h; Inert atmosphere;

4-bromo-3-(bromomethyl)-1-tosyl-1H-indole; In tetrahydrofuran; hexane; at -20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol8022648

Reference yield:

4-bromo-1-tosyl-3-[2-(trimethylsilylethynyl)-1,3-dithian-2-yl]methyl-1H-indole (1085337-59-2) → 1-(4-bromo-1-tosyl-1H-indol-3-yl)-4-(trimethylsilyl)but-3-yn-2-one

Guidance literature:

With N-chloro-succinimide; water; silver nitrate; In acetonitrile; at 0 ℃; for 0.0833333h;

DOI:10.1021/ol8022648

upstream raw materials:

4-bromo-3-(bromomethyl)-1-tosyl-1H-indole

2-<(trimethylsilyl)ethynyl>-1,3-dithiane

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