4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

Base Information

Chemical Name:4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one
CAS No.:99931-65-4
Molecular Formula:C₁₈H₂₀BrFN₄O
Molecular Weight:407.285
Hs Code.:

Synonyms:4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

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Chemical Property of 4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

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Technology Process of 4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

There total 3 articles about 4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 99931-82-5
1-(5-bromopyrimidin-2-yl)piperazine

: 3308-94-9
4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane

: 99931-65-4
4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 36h; Heating;
DOI:10.1021/jm00102a002

Reference yield:

: 20980-22-7
N-(2-pyridinyl)piperazine

: 99931-65-4
4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / Br₂, 1N aq. HCl / 0 - 100 °C

2: 33 percent / K₂CO₃, KI / acetonitrile / 36 h / Heating

With hydrogenchloride; bromine; potassium carbonate; potassium iodide; In acetonitrile;
DOI:10.1021/jm00102a002

Reference yield:

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 99931-65-4
4-[4-(5-Bromo-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / p-toluenesulfonic acid / benzene / 18 h / Heating

2: 33 percent / K₂CO₃, KI / acetonitrile / 36 h / Heating

With potassium carbonate; toluene-4-sulfonic acid; potassium iodide; In acetonitrile; benzene;
DOI:10.1021/jm00102a002