Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

Base Information

Chemical Name:Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2
CAS No.:86095-82-1
Molecular Formula:C₅₃H₈₃Cl₃N₁₀O₁₇
Molecular Weight:1238.66
Hs Code.:

Boc.Gly-Lys<CO.CH2.CH2.COTyr(Bu<sup>t</sup>)OH>-Lys(Troc)-Glu(OBu<sup>t</sup>)-Gln-NH2

Synonyms:Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

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Chemical Property of Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

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Technology Process of Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

There total 8 articles about Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 82215-11-0
Boc.Gly-Lyst)OPh>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

: 86095-82-1
Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

Guidance literature:: With sodium hydroxide; dimethylsulfide; dihydrogen peroxide; In water; N,N-dimethyl-formamide; for 2h; pH: 10.5;
DOI:10.1016/S0040-4020(01)97641-0

Reference yield:

: 82215-14-3
Z-Lys(Troc)-Glu(OBu^t)-Gln-NH₂

: 86095-82-1
Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) dicyclohexylcarbodiimide; 2.) N-hydroxysuccinimide 3.) N-methyl-morpholine / 1.) DMF; 2.) 30 min at 0 deg C; 3.) r.t.

2: 84 percent / H₂O₂, NaOH / dimethylformamide; H₂O / 0.33 h / pH:10.5

3: 1.) N-hydroxybenzotriazole, dicyclohexylcarbodiimide 2.) N-methylmorpholine / 1.) 0 deg C, DMF, 30 min.; 2.) room temp.

4: 64 percent / H₂ / 5percent Pd/C / dimethylformamide / 8 h

5: 33 percent / N-methyl-morpholine, N-hydroxybenzotriazole / dimethylformamide / from 0 deg C to r.t.

6: 81 percent / dimethyl sulphide, NaOH, H₂O₂ / dimethylformamide; H₂O / 2 h / pH: 10.5

With 4-methyl-morpholine; sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; dimethylsulfide; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)97641-0

Reference yield:

: 47594-83-2
α-Benzyloxycarbonyl-ε-troc-L-lysine

: 86095-82-1
Boc.Gly-Lyst)OH>-Lys(Troc)-Glu(OBu^t)-Gln-NH2

Guidance literature:: Multi-step reaction with 8 steps

1: dicyclohexylcarbodiimide / from 0 deg C to r.t.

2: 65 percent / N-methyl-morpholine / Ambient temperature

3: 1.) dicyclohexylcarbodiimide; 2.) N-hydroxysuccinimide 3.) N-methyl-morpholine / 1.) DMF; 2.) 30 min at 0 deg C; 3.) r.t.

4: 84 percent / H₂O₂, NaOH / dimethylformamide; H₂O / 0.33 h / pH:10.5

5: 1.) N-hydroxybenzotriazole, dicyclohexylcarbodiimide 2.) N-methylmorpholine / 1.) 0 deg C, DMF, 30 min.; 2.) room temp.

6: 64 percent / H₂ / 5percent Pd/C / dimethylformamide / 8 h

7: 33 percent / N-methyl-morpholine, N-hydroxybenzotriazole / dimethylformamide / from 0 deg C to r.t.

8: 81 percent / dimethyl sulphide, NaOH, H₂O₂ / dimethylformamide; H₂O / 2 h / pH: 10.5

With 4-methyl-morpholine; sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; dimethylsulfide; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)97641-0