(E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine

Base Information

• Chemical Name: (E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine
• CAS No.: 1173191-66-6
• Molecular Formula: C₁₆H₂₂N₂
• Molecular Weight: 242.364
• Mol file: 1173191-66-6.mol

Synonyms:(E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine

Chemical Property of (E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine

There total 6 articles about (E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Trimethylenediamine (109-76-2,54018-94-9) + 2,2-dimethyl-5-phenylpent-4-ynal (197963-29-4) → (E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine (1173191-66-6)

Guidance literature:

Trimethylenediamine; 2,2-dimethyl-5-phenylpent-4-ynal; In dimethyl sulfoxide; at 20 ℃;

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 2h; stereoselective reaction;

DOI:10.1016/j.mencom.2013.05.006

Reference yield: 72.0%

2-(2-methyl-5-phenylpent-4-yn-2-yl)hexahydropyrimidine (1266235-16-8) + Trimethylenediamine (109-76-2,54018-94-9) → (E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine (1173191-66-6)

Guidance literature:

2-(2-methyl-5-phenylpent-4-yn-2-yl)hexahydropyrimidine; Trimethylenediamine; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 0.5h;

With water; In tetrahydrofuran; hexane;

DOI:10.1007/s11172-010-0261-6

Reference yield: 50.0%

1-chloro-2,2-dimethyl-1-(2-phenylethynyl)cyclopropane (138777-66-9) + Trimethylenediamine (109-76-2,54018-94-9) → (E)-8,8-dimethyl-6-phenylmethyleneoctahydropyrrolo[1,2-a]pyrimidine (1173191-66-6)

Guidance literature:

Trimethylenediamine; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃;

1-chloro-2,2-dimethyl-1-(2-phenylethynyl)cyclopropane; In tetrahydrofuran; hexane; at 20 ℃;

With water; In tetrahydrofuran; hexane;

DOI:10.1016/j.mencom.2008.11.003

upstream raw materials:

1-chloro-2,2-dimethyl-1-(2-phenylethynyl)cyclopropane

Trimethylenediamine

2-(2-methyl-5-phenylpent-4-yn-2-yl)hexahydropyrimidine

1-chloro-3-phenyl-2-propyne