2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester

Base Information

• Chemical Name: 2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester
• CAS No.: 816452-62-7
• Molecular Formula: C₁₆H₁₈BrN₃O₄
• Molecular Weight: 396.241
• Mol file: 816452-62-7.mol

Synonyms:2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester

Chemical Property of 2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester

There total 1 articles about 2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl (2R,5S)-2,5-dibromohexanedioate (868-72-4,53490-47-4,124819-17-6) → 2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester (816452-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / NaN₃ / acetone / 20 °C

2: benzene / 24 h / 20 °C

With sodium azide; In acetone; benzene;

DOI:10.1016/j.tetlet.2004.09.166

Reference yield: 95.0%

2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester (816452-62-7) → 2-azido-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester (816452-59-2)

Guidance literature:

With sodium azide; In acetone; at 20 ℃;

DOI:10.1016/j.tetlet.2004.09.166

Reference yield:

2-bromo-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester (816452-62-7) → 6-oxo-5-(4-phenyl-[1,2,3]triazol-1-yl)-piperidine-2-carboxylic acid methyl ester (816452-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaN₃ / acetone / 20 °C

2: 100 percent / H₂ / 5percent Pd/C / methanol / 20 °C / 760.05 Torr

With sodium azide; hydrogen; 5percent Pd/C; In methanol; acetone;

DOI:10.1016/j.tetlet.2004.09.166

upstream raw materials:

dimethyl (2R,5S)-2,5-dibromohexanedioate

Downstream raw materials:

2-azido-5-(4-phenyl-[1,2,3]triazol-1-yl)-hexanedioic acid dimethyl ester

6-oxo-5-(4-phenyl-[1,2,3]triazol-1-yl)-piperidine-2-carboxylic acid methyl ester