(S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide

Base Information

Chemical Name:(S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide
CAS No.:1383709-26-9
Molecular Formula:C₂₁H₁₉FN₄O₃
Molecular Weight:394.405
Hs Code.:

Synonyms:(S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide

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Technology Process of (S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide

There total 4 articles about (S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1367126-03-1
(S)-2-((4-cyano-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)propanamide

: 1383709-26-9
(S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide

Guidance literature:: With water; PtH(PMe₂O)2H(PMe₂OH); In ethanol; at 100 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 1383709-75-8
(S)-methyl 2-((4,6-dichloropyridin-2-yl)amino)propanoate

: 1383709-26-9
(S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed tube

2: ammonia / methanol / 5 h / 50 - 80 °C / Sealed tube

3: zinc / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 120 °C / Inert atmosphere; Sealed tube

4: water / PtH(PMe₂O)2H(PMe₂OH) / ethanol / 100 °C / Inert atmosphere; Sealed tube

With ammonia; water; sodium carbonate; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1383709-76-9
(S)-methyl 2-((4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)propanoate

: 1383709-26-9
(S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 5 h / 50 - 80 °C / Sealed tube

2: zinc / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 120 °C / Inert atmosphere; Sealed tube

3: water / PtH(PMe₂O)2H(PMe₂OH) / ethanol / 100 °C / Inert atmosphere; Sealed tube

With ammonia; water; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; ethanol; N,N-dimethyl-formamide;