((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester

Base Information

• Chemical Name: ((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester
• CAS No.: 400888-38-2
• Molecular Formula: C₄₀H₄₆O₈
• Molecular Weight: 654.8
• Mol file: 400888-38-2.mol

Synonyms:((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester

Chemical Property of ((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester

There total 3 articles about ((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one (13096-62-3) + bromoacetic acid tert-butyl ester (5292-43-3) → ((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester (400888-38-2)

Guidance literature:

With magnesium; trimethylphosphane; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0957-4166(03)00533-0

Reference yield:

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one (13096-62-3) + t-butyl lithioacetate (150942-98-6) → ((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester (400888-38-2)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1055/s-2001-18097

Reference yield:

2,3,4,6-Tetra-O-benzyl-D-glucopyranose (4291-69-4,6386-24-9,6564-72-3,59531-24-7,69257-52-9,78184-89-1,78609-16-2,78609-17-3,78609-18-4,96553-53-6,104111-61-7,131347-08-5,4132-28-9) → ((2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-hydroxy-tetrahydro-pyran-2-yl)-acetic acid tert-butyl ester (400888-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium chlorochromate; molecular sieves / CH₂Cl₂

2: 90 percent / trimethylphosphine; magnesium; CoCl₂ / tetrahydrofuran / 20 °C

With molecular sieve; magnesium; pyridinium chlorochromate; trimethylphosphane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(03)00533-0

upstream raw materials:

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one

t-butyl lithioacetate

bromoacetic acid tert-butyl ester

2,3,4,6-Tetra-O-benzyl-D-glucopyranose

Downstream raw materials:

((2R,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-benzyloxymethyl-2-cyano-tetrahydro-pyran-2-yl)-acetic acid methyl ester

methyl (2,3,4,6-tetra-O-benzyl-1-hydroxy-D-glucopyranosyl)acetate