(S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

Base Information

Chemical Name:(S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine
CAS No.:107492-21-7
Molecular Formula:C₂₄H₃₉N₂O₆P
Molecular Weight:482.557
Hs Code.:

Synonyms:(S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

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Chemical Property of (S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

Chemical Property:

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Technology Process of (S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

There total 7 articles about (S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126110-76-7
(S)-oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>amino>acetic acid phenylmethyl ester

: 107492-21-7
(S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; Yield given;
DOI:10.1021/jm00167a028

Reference yield:

: 86552-32-1
(4-phenylbutyl)phosphinic acid

: 107492-21-7
(S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

Guidance literature:: Multi-step reaction with 5 steps

1: 5.77 g / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 0.67 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

3: 99 percent / 2.0 N NaOH / dioxane / 2 h / Ambient temperature

4: 52 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 6 h / Ambient temperature

5: H₂ / 20percent Pd/C / methanol / 3 h

With dmap; sodium hydroxide; sodium periodate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm00167a028

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 107492-21-7
(S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / potassium carbonate / dimethylformamide / 2 h / Ambient temperature

2: 5.77 g / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 0.67 h / Ambient temperature

3: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

4: 99 percent / 2.0 N NaOH / dioxane / 2 h / Ambient temperature

5: 52 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 6 h / Ambient temperature

6: H₂ / 20percent Pd/C / methanol / 3 h

With dmap; sodium hydroxide; sodium periodate; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a028