ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate
• CAS No.: 1187376-65-3
• Molecular Formula: C₁₆H₂₀N₂O₃
• Molecular Weight: 288.346

Synonyms:ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate

Chemical Property of ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate

Chemical Property:

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Technology Process of ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate

There total 2 articles about ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

O-methylisourea hemisulfate (29427-58-5,24285-39-0) + 4-methyl-benzaldehyde (104-87-0) + ethyl acetoacetate (141-97-9) → ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate (1187376-65-3)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h;

DOI:10.1016/j.ejmech.2009.02.021

Reference yield:

O-methylisourea hydrosulfate (24285-39-0) + 4-methyl-benzaldehyde (104-87-0) + ethyl acetoacetate (141-97-9) → ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate (1187376-65-3)

Guidance literature:

With piperazine; acetic acid; In toluene; for 3h; Reflux;

DOI:10.1039/C6OB02195F

Reference yield: 66.0%

ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate (1187376-65-3) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → ethyl 6-methyl-2-methoxy-3-([4-methoxyphenyl]-2-oxoethyl)-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1187376-92-6)

Guidance literature:

With pyridine; In dichloromethane; for 7h; Reflux;

DOI:10.1016/j.ejmech.2009.02.021

upstream raw materials:

O-methylisourea hemisulfate

4-methyl-benzaldehyde

ethyl acetoacetate

O-methylisourea hydrosulfate

Downstream raw materials:

ethyl 6-methyl-2-methoxy-3-(2-oxo-2-phenylethyl)-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

ethyl 6-methyl-2-methoxy-3-([4-chlorophenyl]-2-oxoethyl)-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

ethyl 6-methyl-2-methoxy-3-([4-methoxyphenyl]-2-oxoethyl)-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

C₁₇H₂₂N₂O₃

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