(5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

Base Information

Chemical Name:(5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate
CAS No.:1345817-61-9
Molecular Formula:C₂₃H₃₂N₂O₄
Molecular Weight:400.518
Hs Code.:

Synonyms:(5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

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Chemical Property of (5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

There total 6 articles about (5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 923010-92-8,923010-93-9,923010-94-0
benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

: 1345817-62-0
(5R)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

: 1345817-61-9
(5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

Guidance literature:: With CHIRALPAK AD-H; In ethanol; hexane; at 25 ℃; Purification / work up; Resolution of racemate;

Reference yield:

: 1263283-85-7
C₁₀H₁₇NO₂

: 1345817-61-9
(5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C / Cooling with ice

2: Resolution of racemate

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2011.08.117

Reference yield:

: 923009-61-4
C₁₆H₂₇NO₅

: 1345817-61-9
(5S)-benzyl 4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1 h / 20 °C

2: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C

3: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C / Cooling with ice

4: Resolution of racemate

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2011.08.117