tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate

Base Information

Chemical Name:tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate
CAS No.:1245941-92-7
Molecular Formula:C₂₃H₃₇NO₇S₂
Molecular Weight:503.681
Hs Code.:

Synonyms:tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate

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Chemical Property of tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate

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Technology Process of tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate

There total 5 articles about tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1245941-96-1
tert-butyl N-(tert-butoxycarbonyl)-S-(3-hydroxypropyl)-homocysteinate

: 98-59-9
p-toluenesulfonyl chloride

: 1245941-92-7
tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate

Guidance literature:: With N,N,N',N'-tetramethylhexamethylenediamine; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm101513q

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1245941-92-7
tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / 1,4-dioxane; water / 20 °C

2: dichloromethane / 20 °C

3: tributylphosphine / N,N-dimethyl-formamide / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

5: N,N,N',N'-tetramethylhexamethylenediamine / acetonitrile / 4 h / 20 °C / Inert atmosphere

With tributylphosphine; N,N,N',N'-tetramethylhexamethylenediamine; sodium carbonate; potassium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm101513q

Reference yield:

: 130981-51-0
(2S,2'S)-4,4'-disulfanediylbis(2-(tert-butoxycarbonyl)amino)butanoic acid

: 1245941-92-7
tert-butyl N-(tert-butoxycarbonyl)-S-(3-tosyloxypropyl)-homocysteinate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 20 °C

2: tributylphosphine / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

4: N,N,N',N'-tetramethylhexamethylenediamine / acetonitrile / 4 h / 20 °C / Inert atmosphere

With tributylphosphine; N,N,N',N'-tetramethylhexamethylenediamine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm101513q