N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide

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Chemical Name:N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide
CAS No.:126410-54-6
Molecular Formula:C₄₇H₅₂N₂O₇
Molecular Weight:756.939
Hs Code.:

Synonyms:N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide

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Chemical Property of N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide

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Technology Process of N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide

There total 16 articles about N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(1S,2S,4R)-1-(4-Benzyloxy-benzyl)-5-(4-benzyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

: 126410-54-6
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 20h; Yield given;
DOI:10.1021/jm00088a003

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 126410-54-6
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide

Guidance literature:: Multi-step reaction with 9 steps

1: CH₂Cl₂ / 18 h / Ambient temperature

2: 13.2 g / monoperoxyphthalic acid magnesium salt hexahydrate / methanol / 48 h

3: 55 percent / Na, ethanol

4: Na / ethanol / 2.55 h / 50 °C

5: 1.) 1M LiOH / 1.) DME, 12 h, 2.) toluene, reflux, 18 h

6: 100 percent / aq. LiOH / 1,2-dimethoxy-ethane / 3 h

7: 100 percent / imidazole / dimethylformamide / 0.07 h

8: 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 17 h

9: tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; ethanol; dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride; tetrabutyl ammonium fluoride; sodium; 1-hydroxybenzotriazol-hydrate; Monoperoxyphthalic acid, magnesium salt; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a003

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
(+/-)-cis-1-amino-indan-2-ol

: 126410-54-6
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-<<4-(benzyloxy)phenyl>methyl>hexanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 16 h

2: 40 percent / trifluoroacetic acid / CHCl₃ / 2.5 h

3: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating

4: 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 17 h

5: tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h

With 4-methyl-morpholine; sodium hydroxide; dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride; tetrabutyl ammonium fluoride; 1-hydroxybenzotriazol-hydrate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a003