N₃-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide

Base Information

• Chemical Name: N₃-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide
• CAS No.: 1256382-63-4
• Molecular Formula: C₂₉H₃₈N₂O₂
• Molecular Weight: 446.633

Synonyms:N₃-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide

Chemical Property of N₃-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide

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Technology Process of N₃-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide

There total 6 articles about N₃-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

memantine* (19982-08-2,51052-62-1) + 4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylic acid (1256382-48-5) → N3-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide (1256382-63-4)

Guidance literature:

4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

memantine*; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/jm100286k

Reference yield: 62.0%

→ N3-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide (1256382-63-4)

Guidance literature:

Reference yield:

ethyl 4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylate (1256382-37-2) → N3-(1-(3,5-dimethyl)adamantyl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxamide (1256382-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 6 h / Reflux

1.2: pH 2

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 12 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm100286k

upstream raw materials:

ethyl 4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylate

memantine*

4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylic acid

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

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