(1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane

Base Information

• Chemical Name: (1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane
• CAS No.: 347868-84-2
• Molecular Formula: C₁₆H₂₀Br₂N₂S₂
• Molecular Weight: 464.288
• Mol file: 347868-84-2.mol

Synonyms:(1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane

Chemical Property of (1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane

There total 3 articles about (1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diiminocyclohexane → (1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane (347868-84-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃;

DOI:10.1016/S0040-4039(01)00387-2

Reference yield:

5-bromo-2-thiophencarboxaldehyde (4701-17-1) → (1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane (347868-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 3 Angstroem molecular sieves / CH₂Cl₂

2: 85 percent / sodium borohydride / methanol / 20 °C

With sodium tetrahydroborate; 3 A molecular sieve; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(01)00387-2

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → (1R,2R)-N,N'-bis(5-bromothiophen-2-ylmethyl)-1,2-diaminocyclohexane (347868-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 3 Angstroem molecular sieves / CH₂Cl₂

2: 85 percent / sodium borohydride / methanol / 20 °C

With sodium tetrahydroborate; 3 A molecular sieve; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(01)00387-2

upstream raw materials:

5-bromo-2-thiophencarboxaldehyde

(1R,2R)-1,2-diaminocyclohexane