tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate

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Chemical Name:tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate
CAS No.:339555-40-7
Molecular Formula:C₂₈H₃₄N₂O₃
Molecular Weight:446.59
Hs Code.:

Synonyms:tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate

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Chemical Property of tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate

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Technology Process of tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate

There total 4 articles about tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₇NO₃

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 339555-40-7
tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at 30 ℃; for 1h;

C₁₃H₁₇NO₃; In tetrahydrofuran; hexane; at -65 - 57 ℃; for 1.5h;

Reference yield:

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 339555-37-2
tert-butyl (2E)-3-(6-methoxypyridin-3-yl)prop-2-enoate

: 339555-40-7
tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -65 - -57 ℃;
DOI:10.1021/jo030297u

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 339555-40-7
tert-butyl (3S)-3-{benzyl[(1R)-1-phenylethyl]amino}-3-(6-methoxypyridin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: (o-tolyl)3P; Et₃N; NMP / Pd(OAc)2 / 12 h / 90 °C

2: n-BuLi / tetrahydrofuran; hexane / -65 - -57 °C

With 1-methyl-pyrrolidin-2-one; n-butyllithium; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; hexane; 1: Heck reaction / 2: Michael addition;
DOI:10.1021/jo030297u