(S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate

Base Information

• Chemical Name: (S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate
• CAS No.: 1004751-80-7
• Molecular Formula: C₁₆H₂₂ClNO₃
• Molecular Weight: 311.809
• Mol file: 1004751-80-7.mol

Synonyms:(S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate

Chemical Property of (S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of (S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate

There total 1 articles about (S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-methyl 1-[(S)-3-(benzyloxy)-2-hydroxypropyl]pyrrolidine-2-carboxylate (1004751-79-4) → (S)-methyl 1-[(S)-3-(benzyloxy)-2-chloropropyl]pyrrolidine-2-carboxylate (1004751-81-8) + (S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate (1004751-80-7)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In dichloromethane; at 20 ℃; for 5h; Title compound not separated from byproducts.;

DOI:10.1002/ejoc.200700616

Reference yield: 58.0%

(S)-methyl 1-[(S)-3-(benzyloxy)-2-chloropropyl]pyrrolidine-2-carboxylate (1004751-81-8) + (S)-methyl 1-[(S)-3-(benzyloxy)-1-chloropropan-2-yl]pyrrolidine-2-carboxylate (1004751-80-7) → (5S,7R)-methyl 7-[(benzyloxy)methyl]-1-axabicyclo[3.2.0]heptane-5-carboxylate (1004751-82-9)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -90 ℃;

DOI:10.1002/ejoc.200700616

upstream raw materials:

(S)-methyl 1-[(S)-3-(benzyloxy)-2-hydroxypropyl]pyrrolidine-2-carboxylate

Downstream raw materials:

(5S,7R)-methyl 7-[(benzyloxy)methyl]-1-axabicyclo[3.2.0]heptane-5-carboxylate