1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

Base Information

Chemical Name:1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea
CAS No.:1299487-26-5
Molecular Formula:C₂₆H₂₇F₆N₃O₄
Molecular Weight:559.508
Hs Code.:

Synonyms:1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

Suppliers and Price of 1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

There total 4 articles about 1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299487-30-1
1-(cyclopropylmethyl)-3-(4-(piperidin-4-yloxy)phenyl)urea

: 16261-80-6
4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzoic acid

: 1299487-26-5
1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

Guidance literature:: 1-(cyclopropylmethyl)-3-(4-(piperidin-4-yloxy)phenyl)urea; 4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzoic acid; With triethylamine; In dichloromethane; at 20 ℃;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In dichloromethane; ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 123-30-8
4-amino-phenol

: 1299487-26-5
1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: cesium fluoride / ISOPROPYLAMIDE / 85 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 20 °C

4.2: 1 h / 20 °C

With triethylamine; cesium fluoride; trifluoroacetic acid; In dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 1299487-29-8
tert-butyl 4-(4-(3-(cyclopropylmethyl)ureido)phenoxy)piperidine-1-carboxylate

: 1299487-26-5
1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzoyl)piperidin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: triethylamine / dichloromethane / 20 °C

2.2: 1 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;