Technology Process of Boc-O-Bn-D-Ser-NH2
There total 1 articles about Boc-O-Bn-D-Ser-NH2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-Boc-D-serine(Bzl)-OH;
With
chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
With
ammonium chloride;
In
tetrahydrofuran; water;
at 0 ℃;
for 0.5h;
DOI:10.1016/j.tetasy.2017.10.015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trifluoroacetic acid / 0.33 h
2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 100 °C
3: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 120 °C / Inert atmosphere
4: potassium carbonate; dihydrogen peroxide / water; dimethyl sulfoxide / 0.08 h / 90 °C
With
dihydrogen peroxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 0.33 h
2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 100 °C
3: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 120 °C / Inert atmosphere
With
potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane; dimethyl sulfoxide;
