(3Z)-5-METHYL-1H-INDOLE-2,3-DIONE 3-OXIME

Base Information

• Chemical Name: (3Z)-5-METHYL-1H-INDOLE-2,3-DIONE 3-OXIME
• CAS No.: 13208-98-5
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Hs Code.: 2933790090
• Mol file: 13208-98-5.mol

Synonyms:5-methylisatin-3-oxime;5-Methyl-indolin-2,3-dion-3-oxim;5-methyl-indoline-2,3-dione-3-oxime;5-methylisatinmonoxime;

Chemical Property of (3Z)-5-METHYL-1H-INDOLE-2,3-DIONE 3-OXIME

Chemical Property:

• Vapor Pressure: 1.01E-07mmHg at 25°C
• Boiling Point: 390.8°C at 760 mmHg
• Flash Point: 190.2°C
• PSA: 61.69000
• Density: 1.42g/cm³
• LogP: 1.26340

Purity/Quality:

98%min ^*data from raw suppliers

3-(hydroxyimino)-5-methyl-2,3-dihydro-1H-indol-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3Z)-5-METHYL-1H-INDOLE-2,3-DIONE 3-OXIME

There total 5 articles about (3Z)-5-METHYL-1H-INDOLE-2,3-DIONE 3-OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-nitro-4-methyl acetanilide (143884-72-4) → 5-methylisatin-3-oxime (13208-98-5)

Guidance literature:

With sulfuric acid; Ambient temperature;

DOI:10.1055/s-1992-26223

Reference yield: 37.0%

morpholine (110-91-8,99108-56-2) + 5-methyl-2,3-indoledione 3-oxime O-(2-nitrobenzene)sulfonate → 5-methyl-2,3-indoledione 3-oxime (13208-98-5) + 4‐(2‐nitrobenzenesulfonyl)morpholine (99069-26-8)

Guidance literature:

In 1,4-dioxane; at 20 ℃;

DOI:10.1007/s10593-005-0114-7

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 5-methylisatin-3-oxime (13208-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / aq. ethanol / 24 h / Heating

2: 73 percent / aq.KOH / 5 h / Heating

3: 57 percent / conc.H₂SO₄ / Ambient temperature

With potassium hydroxide; sulfuric acid; In ethanol;

DOI:10.1055/s-1992-26223

upstream raw materials:

5-methyl-indole-2,3-dione

2-nitro-4-methyl acetanilide

p-toluidine

(E)-4-methyl-N-(1-(methylthio)-2-nitrovinyl)aniline

Downstream raw materials:

2-amino-5-methylbenzonitrile

5-methyl-indole-2,3-dione