4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

Base Information

Chemical Name:4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate
CAS No.:1443467-70-6
Molecular Formula:C₅₃H₈₂ClNO₇
Molecular Weight:880.69
Hs Code.:

4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

Synonyms:4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

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Chemical Property of 4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

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Technology Process of 4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

There total 16 articles about 4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1443467-68-2
tert-butyl 4-chlorobenzyl(2-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-3a-yl)-2-oxoethyl)carbamate

: 1443467-69-3
4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

: 1443467-70-6
4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 55976-58-4
((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-9-acetoxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-3a-yl)methyl acetate

: 1443467-69-3
4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

: 1443467-70-6
4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium hydroxide; water / toluene; ethanol / 4 h / 20 °C

2.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

3.1: triethylamine / 60 °C

4.1: sodium tetrahydroborate; methanol; nickel dichloride / 0.17 h / 0 °C

5.1: zinc(II) chloride / methanol; 1,2-dichloro-ethane / 1 h / 80 °C

5.2: 1 h / 20 °C

6.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C

7.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

8.1: water; sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

10.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C

With methanol; dmap; sodium tetrahydroborate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; potassium hydroxide; sodium hydroxide; nickel dichloride; zinc(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: (3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(hydroxymethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate

: 1443467-69-3
4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

: 1443467-70-6
4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

2.1: triethylamine / 60 °C

3.1: sodium tetrahydroborate; methanol; nickel dichloride / 0.17 h / 0 °C

4.1: zinc(II) chloride / methanol; 1,2-dichloro-ethane / 1 h / 80 °C

4.2: 1 h / 20 °C

5.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C

6.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

7.1: water; sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

9.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C

With methanol; dmap; sodium tetrahydroborate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; sodium hydroxide; nickel dichloride; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;