(2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

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Chemical Name:(2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid
CAS No.:934471-24-6
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:(2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

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Chemical Property of (2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

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Technology Process of (2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

There total 3 articles about (2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 934471-11-1
1-tert-butyl 2-methyl (2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1,2-pyrrolidinedicarboxylate

: 934471-24-6
(2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2007.01.033

Reference yield:

: 1-tert-butyl 2-methyl (2S)-4-(4-benzyloxy-2,6-dimethylphenyl)-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate

: 934471-24-6
(2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / hydrogen / Pd/C / methanol / 13 h / 20 °C / atmospheric pressure

2: 79 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

3: 100 percent / NaOH / methanol; H₂O / 6 h / 20 °C

With sodium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.01.033

Reference yield:

: 934471-10-0
1-tert-butyl 2-methyl (2S,4R)-4-(4-hydroxy-2,6-dimethylphenyl)-1,2-pyrrolidinedicarboxylate

: 934471-24-6
(2S,4R)-4-(4-benzyloxy-2,6-dimethylphenyl)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

2: 100 percent / NaOH / methanol; H₂O / 6 h / 20 °C

With sodium hydroxide; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.01.033