C₁₂H₁₄N₄

Base Information

• Chemical Name: C₁₂H₁₄N₄
• CAS No.: 1608506-45-1
• Molecular Formula: C₁₂H₁₄N₄
• Molecular Weight: 214.27
• Mol file: 1608506-45-1.mol

Synonyms:C₁₂H₁₄N₄

Chemical Property of C₁₂H₁₄N₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₄N₄

There total 5 articles about C₁₂H₁₄N₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H21NO2S → C12H14N4 (1608506-45-1)

Guidance literature:

With sodium azide; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 40 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol501058a

Reference yield:

diethyl 2-benzyl-2-(2-cyanoethyl)malonate (10444-15-2) → C12H14N4 (1608506-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium chloride / dimethyl sulfoxide / 6 h / 140 °C / Inert atmosphere

2: lithium chloride; potassium borohydride / tetrahydrofuran / 23 h / Inert atmosphere; Reflux

3: triethylamine; dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere

4: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With dmap; sodium azide; potassium borohydride; tetra-(n-butyl)ammonium iodide; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/ol501058a

Reference yield:

4-Benzyl-5-hydroxy-pentansaeurenitril (10444-26-5) → C12H14N4 (1608506-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere

2: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With dmap; sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol501058a

upstream raw materials:

diethyl 2-benzylmalonate

diethyl 2-benzyl-2-(2-cyanoethyl)malonate

2-benzyl-4-cyano-butyric acid ethyl ester

4-Benzyl-5-hydroxy-pentansaeurenitril

Downstream raw materials:

5-azido-4-benzylpentanoic acid

C₁₂H₁₄ClN₃O