ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate

Base Information

Chemical Name:ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate
CAS No.:1360060-68-9
Molecular Formula:C₂₄H₂₉ClN₂O₃
Molecular Weight:428.959
Hs Code.:

Synonyms:ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate

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Chemical Property of ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate

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Technology Process of ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate

There total 4 articles about ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: C₁₉H₁₈BrClO₃

: 1360060-68-9
ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate

Guidance literature:: In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃; for 1h;
DOI:10.1016/j.bmc.2011.12.058

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1360060-68-9
ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; magnesium chloride / 1,2-dichloro-ethane / 1 h / 40 °C

1.2: 3 h / 70 °C

2.1: sodium tert-pentoxide / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 2 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

4.1: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 80 °C

With sodium tert-pentoxide; potassium carbonate; triethylamine; magnesium chloride; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2011.12.058

Reference yield:

: 1360060-12-3
ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-hydroxybenzoate

: 1360060-68-9
ethyl 3-[(E)-2-(4-chlorophenyl)vinyl]-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 80 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.058