(S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester
• CAS No.: 118388-72-0
• Molecular Formula: C₁₅H₂₆BrNO₃
• Molecular Weight: 348.28

Synonyms:(S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester

Chemical Property of (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester

There total 3 articles about (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

(S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate (118388-73-1) → (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester (118388-72-0)

Guidance literature:

With hydrogen bromide; In diethyl ether; at -20 ℃;

DOI:10.1021/jm00164a058

Reference yield:

(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid (37736-82-6) → (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester (118388-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-methylpiperidine / ethyl acetate / 0.17 h / -20 °C

2: ethyl acetate; diethyl ether / 2 °C / overnight

3: 86.4 percent / HBr gas / diethyl ether / -20 °C

With N-methylcyclohexylamine; hydrogen bromide; In diethyl ether; ethyl acetate;

DOI:10.1021/jm00164a058

Reference yield:

C19H33NO6 → (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester (118388-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate; diethyl ether / 2 °C / overnight

2: 86.4 percent / HBr gas / diethyl ether / -20 °C

With hydrogen bromide; In diethyl ether; ethyl acetate;

DOI:10.1021/jm00164a058

upstream raw materials:

(S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate

(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid

Downstream raw materials:

((S)-4-{(S)-1-[(S)-2-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-1-cyclohexylmethyl-6-methyl-2-oxo-heptyl)-carbamic acid tert-butyl ester

((S)-4-{(S)-1-[(S)-2-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-6-methyl-heptyl)-carbamic acid tert-butyl ester

2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>-2-(2-methylpropyl)propanedioic acid bis(phenylmethyl) ester

(S)-5-tert-Butoxycarbonylamino-6-cyclohexyl-2-isobutyl-4-oxo-hexanoic acid

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