1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide

Base Information

Chemical Name:1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide
CAS No.:912848-72-7
Molecular Formula:BrH*C₁₂H₁₃F₃N₂O
Molecular Weight:339.155
Hs Code.:

Synonyms:1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide

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Chemical Property of 1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide

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Technology Process of 1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide

There total 1 articles about 1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 86256-59-9
2-methyl-4-trifluoromethoxy-phenylamine

: 5332-06-9
4-bromobutanenitrile

: 912848-72-7
1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 100 - 115 ℃; for 4h;
DOI:10.1021/op100147h

Reference yield:

: 912848-72-7
1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide

: 4-iodo-6-methyl-1-[2-methyl-4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 2-methyltetrahydrofuran; water

1.2: 8 h / Reflux

2.1: potassium tert-butylate / 2-methyltetrahydrofuran / 9 h / Inert atmosphere; Reflux

3.1: pyridine / dichloromethane / 1 h / -78 °C

4.1: dimethylsulfone; potassium iodide / N,N-dimethyl-formamide / 1.5 h / 85 °C

With pyridine; dimethylsulfone; potassium tert-butylate; potassium iodide; sodium hydroxide; In 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.2: Michael addition;
DOI:10.1021/op100147h

Reference yield:

: 912848-72-7
1-[2-methyl-4-(trifluoromethoxy)phenyl]pyrrolidin-2-imine hydrobromide

: 912848-78-3
6-methyl-1-[2-methyl-4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 2-methyltetrahydrofuran; water

1.2: 8 h / Reflux

2.1: potassium tert-butylate / 2-methyltetrahydrofuran / 9 h / Inert atmosphere; Reflux

With potassium tert-butylate; sodium hydroxide; In 2-methyltetrahydrofuran; water; 1.2: Michael addition;
DOI:10.1021/op100147h