2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

Base Information

Chemical Name:2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione
CAS No.:532427-83-1
Molecular Formula:C₁₈H₂₀BrClN₂O₂
Molecular Weight:411.726
Hs Code.:

2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-<i>c</i>]pyrimidine-1,3-dione

Synonyms:2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

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Chemical Property of 2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

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Technology Process of 2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

There total 7 articles about 2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.9%

: 110-52-1
1,4-dibromo-butane

: 231615-32-0
4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

: 532427-83-1
2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

Guidance literature:: With potassium carbonate; In acetone; for 25h; Heating;
DOI:10.1016/S0014-827X(02)01274-0

Reference yield:

: 884851-44-9
2-(4-bromobutyl)-4-(2-chlorophenyl)-2H-pyrido[1,2-c]pyrimidine-1,3-dione

: 532427-83-1
2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

Guidance literature:: With platinum on activated charcoal; hydrogen; acetic acid; at 50 ℃; for 10h; under 45603.1 Torr;
DOI:10.1016/j.ejmech.2009.07.007

Reference yield:

: 2856-63-5
2-Chlorophenylacetonitrile

: 532427-83-1
2-(4-bromo-butyl)-4-(2-chloro-phenyl)-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / dimethyl sulfoxide

2: sulfuric acid; acetic acid

3: sodium ethanolate / ethanol

4: potassium carbonate / acetone

5: palladium 10% on activated carbon; hydrogen / ethanol

With sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium ethanolate; potassium carbonate; acetic acid; potassium hydroxide; In ethanol; dimethyl sulfoxide; acetone;
DOI:10.1016/j.ejmech.2015.05.003