3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid

Base Information

Chemical Name:3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid
CAS No.:394734-86-2
Molecular Formula:C₂₁H₃₄N₂O₅
Molecular Weight:394.511
Hs Code.:

Synonyms:3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid

There total 4 articles about 3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 394731-25-0
(S)-cyclohexyl-isobutoxycarbonylamino-acetic acid

: 394734-86-2
3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / HATU; diisopropylethylamine / acetonitrile

2: 96 percent / CrO₃; aq. H₂SO₄ / 3 h / 0 °C

With chromium(VI) oxide; sulfuric acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; 2: Jones oxidation;
DOI:10.1021/jm060077j

Reference yield:

: (S)-cyclohexylglycine hydrochloride

: 394734-86-2
3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃ / acetonitrile; H₂O / 17 h / 20 °C

2: 67 percent / HATU; diisopropylethylamine / acetonitrile

3: 96 percent / CrO₃; aq. H₂SO₄ / 3 h / 0 °C

With chromium(VI) oxide; sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; acetonitrile; 3: Jones oxidation;
DOI:10.1021/jm060077j

Reference yield:

: 394734-84-0
(1R,2S,5S)-(6,6-dimethyl-3-azabicyclo[3.1.0]hex-2-yl)methanol

: 394734-86-2
3-(2-(S)-cyclohexyl-2-isobutoxycarbonylaminoacetyl)-1-(R),5-(S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / HATU; diisopropylethylamine / acetonitrile

2: 96 percent / CrO₃; aq. H₂SO₄ / 3 h / 0 °C

With chromium(VI) oxide; sulfuric acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; 2: Jones oxidation;
DOI:10.1021/jm060077j