C₄₁H₄₈O₇S₂

Base Information

• Chemical Name: C₄₁H₄₈O₇S₂
• CAS No.: 344315-46-4
• Molecular Formula: C₄₁H₄₈O₇S₂
• Molecular Weight: 716.96
• Mol file: 344315-46-4.mol

Synonyms:C₄₁H₄₈O₇S₂

Chemical Property of C₄₁H₄₈O₇S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₄₈O₇S₂

There total 23 articles about C₄₁H₄₈O₇S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C50H68O7S2Si (344315-41-9) → C41H48O7S2 (344315-46-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)00286-6

Reference yield:

(2S,3S,4R,4aR,6R,7S,8aR)-2-Allyl-3,4-bis-benzyloxy-6-(3,3-dibromo-allyl)-7-(1-ethoxy-ethoxy)-octahydro-pyrano[3,2-b]pyran → C41H48O7S2 (344315-46-4)

Guidance literature:

Multi-step reaction with 23 steps

1.1: n-BuLi / tetrahydrofuran

2.1: Amberlyst-15E / methanol

3.1: Co₂(CO)8; BF₃*OEt₂ / CH₂Cl₂

3.2: propargyl alcohol / 1,2-dichloro-ethane / 60 °C

4.1: Jones' reagent / acetone

4.2: 88 percent / PdCl₂; CuCl / dimethylformamide; H₂O

5.1: 86 percent / I(collidine)2PF₆- / CH₂Cl₂

6.1: 90 percent / BF₃*OEt₂ / CH₂Cl₂

7.1: DIBAL-H / CH₂Cl₂

8.1: DBU / tetrahydrofuran

9.1: 81 percent / K₂CO₃ / methanol

10.1: 90 percent / BF₃*OEt₂ / CH₂Cl₂

11.1: p-nitro benzoic acid; DEAD; PPh₃ / toluene

11.2: 94 percent / K₂CO₃ / methanol

12.1: PPTS / CH₂Cl₂

13.1: n-BuLi / tetrahydrofuran

14.1: Amberlyst-15E / methanol

15.1: Jones' reagent / acetone

16.1: I(collidine)2PF₆ / CH₂Cl₂

17.1: BF₃*OEt₂ / CH₂Cl₂

18.1: DIBAL-H / CH₂Cl₂

19.1: DBU / tetrahydrofuran

20.1: 69 percent / n-BuLi

21.1: 65 percent / BF₃*OEt₂ / CH₂Cl₂

22.1: 83 percent / TBAF / tetrahydrofuran

With n-butyllithium; jones' reagent; dicobalt octacarbonyl; Amberlyst-15E; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; 4.1: Wacker oxidation / 11.1: modified Mitsunobu inversion;

DOI:10.1016/S0040-4039(01)00286-6

Reference yield:

(2S,3S,4R,4aR,5aR,8S,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol (344315-43-1) → C41H48O7S2 (344315-46-4)

Guidance literature:

Multi-step reaction with 12 steps

1: PPTS / CH₂Cl₂

2: n-BuLi / tetrahydrofuran

3: Amberlyst-15E / methanol

4: Jones' reagent / acetone

5: I(collidine)2PF₆ / CH₂Cl₂

6: BF₃*OEt₂ / CH₂Cl₂

7: DIBAL-H / CH₂Cl₂

8: DBU / tetrahydrofuran

9: 69 percent / n-BuLi

10: 65 percent / BF₃*OEt₂ / CH₂Cl₂

11: 83 percent / TBAF / tetrahydrofuran

With n-butyllithium; jones' reagent; Amberlyst-15E; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1016/S0040-4039(01)00286-6

upstream raw materials:

C₅₀H₆₈O₇S₂Si

(2S,3S,4R,4aR,5aR,8S,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol

(2S,3S,4R,4aR,5aR,8R,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol

2-((2S,3S,4R,4aR,5aR,9R,10aS,11aR)-2-Allyl-3,4-bis-benzyloxy-7-triethylsilanyl-2,3,4,4a,5a,6,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-9-yl)-ethanol