4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride

Base Information

• Chemical Name: 4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride
• CAS No.: 1434817-67-0
• Molecular Formula: C₁₃H₁₀F₃NS*ClH
• Molecular Weight: 305.751

Synonyms:4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride

Chemical Property of 4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride

Chemical Property:

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Technology Process of 4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride

There total 1 articles about 4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.9%

4-(4-tert-butylsulfanyl-3-trifluoromethyl-phenyl)-2-methylpyridine (1434817-81-8) → 4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride (1434817-67-0)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 22h; Reflux;

Reference yield:

4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride (1434817-67-0) + methanesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidin-3-yl ester (1434818-87-7) → (2S,4R)-4-[4-(2-methylpyridin-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide (1434818-59-3)

Guidance literature:

With sodium t-butanolate; In tetrahydrofuran; at 0 - 50 ℃; for 5h;

Reference yield:

4-(2-methyl-pyridin-4-yl)-2-trifluoromethylbenzenethiol hydrochloride (1434817-67-0) + methanesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidin-3-yl ester (1434818-87-7) → (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methylpyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:

With sodium t-butanolate; In tetrahydrofuran; at 0 - 50 ℃; for 5h;

upstream raw materials:

4-(4-tert-butylsulfanyl-3-trifluoromethyl-phenyl)-2-methylpyridine

Downstream raw materials:

(2S,4R)-4-[4-(2-methylpyridin-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

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