N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone

Base Information

• Chemical Name: N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone
• CAS No.: 1449655-53-1
• Molecular Formula: C₁₇H₂₁NO₄
• Molecular Weight: 303.358
• Mol file: 1449655-53-1.mol

Synonyms:N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone

Chemical Property of N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone

There total 4 articles about N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-bromoanisole (578-57-4) + tert-butyl 4-oxopyridine-1-carboxylate (332940-69-9) → N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone (1449655-53-1)

Guidance literature:

With chloro-trimethyl-silane; iodine; magnesium; In tetrahydrofuran; at 50 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/jo400936z

Reference yield: 80.0%

C7H7OZn(1+)*Cl(1-) + tert-butyl 4-oxopyridine-1-carboxylate (332940-69-9) → N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone (1449655-53-1)

Guidance literature:

tert-butyl 4-oxopyridine-1-carboxylate; With chlorobis(ethylene)rhodium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at -5 ℃; for 0.25h; Inert atmosphere;

C₇H₇OZn⁽¹⁺⁾*Cl^(1-); With chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.3390/molecules22050723

Reference yield:

tert-butyl formate (762-75-4) → N-boc-2-(2-methoxyphenyl)-2,3-dihydro-4-pyridone (1449655-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tert-butyl alcohol / 12 h / 20 - 50 °C / Inert atmosphere

2: magnesium; chloro-trimethyl-silane; iodine / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

With chloro-trimethyl-silane; iodine; sodium hydride; magnesium; In tetrahydrofuran; tert-butyl alcohol;

DOI:10.1021/jo400936z

upstream raw materials:

2-bromoanisole

tert-butyl 4-oxopyridine-1-carboxylate

tert-butyl formate

pyridin-4-ol

Refernces

• 1、 Guo, Fenghai,Dhakal, Ramesh C.,Dieter, R. Karl. "Conjugate addition reactions of N -carbamoyl-4-pyridones and 2,3-dihydropyridones with grignard reagents in the absence of Cu(I) Salts". . p. 8451 - 8464. Retrieved 2013/09/24.