(1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane

Base Information

• Chemical Name: (1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane
• CAS No.: 1160615-47-3
• Molecular Formula: C₁₇H₂₄O₂Si
• Molecular Weight: 288.462
• Mol file: 1160615-47-3.mol

Synonyms:(1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane

Chemical Property of (1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane

There total 2 articles about (1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 3-(4-methylphenyl)acrylate (7560-43-2,20754-20-5,50363-84-3) + Br(1-)*C17H33OSeSi(1+) → (1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane (1160615-47-3)

Guidance literature:

Br^(1-)*C₁₇H₃₃OSeSi⁽¹⁺⁾; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.0833333h; Inert atmosphere;

methyl 3-(4-methylphenyl)acrylate; In tetrahydrofuran; toluene; at -78 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.200801936

Reference yield:

methyl 3-(4-methylphenyl)acrylate (7560-43-2,20754-20-5,50363-84-3) + Br(1-)*C18H35OSeSi(1+) → (1R,2R,3R)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane (1160615-47-3) + (1S,2S,3S)-1-methoxycarbonyl-trans-2-(4-methylphenyl)-cis-3-[(E)-2-(trimethylsilyl)vinyl]cyclopropane

Guidance literature:

Br^(1-)*C₁₈H₃₅OSeSi⁽¹⁺⁾; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.0833333h; Inert atmosphere;

methyl 3-(4-methylphenyl)acrylate; In tetrahydrofuran; toluene; at -78 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.200801936

upstream raw materials:

methyl 3-(4-methylphenyl)acrylate