1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine

Base Information

Chemical Name:1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine
CAS No.:1358694-10-6
Molecular Formula:C₂₄H₁₈F₅N₃
Molecular Weight:443.419
Hs Code.:

Synonyms:1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine

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Chemical Property of 1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine

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Technology Process of 1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine

There total 7 articles about 1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1358694-18-4
N-(3,5-difluorobenzyl)pyrimidin-2-amine

: 1358694-25-3
2-bromo-3-(4'-(trifluoromethyl)biphenyl-4-yl)propanal

: 1358694-10-6
1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine

Guidance literature:: N-(3,5-difluorobenzyl)pyrimidin-2-amine; 2-bromo-3-(4'-(trifluoromethyl)biphenyl-4-yl)propanal; In acetonitrile; at 150 ℃; for 1.25h; Microwave irradiation;

With hydrazine hydrate; In acetonitrile; at 100 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.12.016

Reference yield:

: 356058-16-7
3-(4'-(trifluoromethyl)biphenyl-4-yl)propan-1-ol

: 1358694-10-6
1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 0 °C

2.1: hydrogenchloride; 5,5-dibromobarbituric acid / 1,4-dioxane; diethyl ether / 20 h / 20 °C

3.1: acetonitrile / 1.25 h / 150 °C / Microwave irradiation

3.2: 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; 5,5-dibromobarbituric acid; pyridinium chlorochromate; In 1,4-dioxane; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2011.12.016

Reference yield:

: 1358694-37-7
methyl 3-(4-(4-(trifluoromethyl)phenyl)phenyl)propanoate

: 1358694-10-6
1-(3,5-difluorobenzyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 5 h / 0 - 20 °C / Inert atmosphere

1.2: 0 °C

2.1: pyridinium chlorochromate / dichloromethane / 0 °C

3.1: hydrogenchloride; 5,5-dibromobarbituric acid / 1,4-dioxane; diethyl ether / 20 h / 20 °C

4.1: acetonitrile / 1.25 h / 150 °C / Microwave irradiation

4.2: 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; lithium aluminium tetrahydride; 5,5-dibromobarbituric acid; pyridinium chlorochromate; In 1,4-dioxane; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2011.12.016