6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Base Information

Chemical Name:6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one
CAS No.:1196546-34-5
Molecular Formula:C₂₄H₂₀FN₅O₂
Molecular Weight:429.454
Hs Code.:

Synonyms:6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

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Chemical Property of 6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Chemical Property:

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Technology Process of 6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

There total 7 articles about 6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 893441-85-5
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-2-one

: 1196551-90-2
4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)-3-(3-fluorophenyl)morpholine

: 1196546-34-5
6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Guidance literature:: With water; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 150 ℃; for 20h; Inert atmosphere;

Reference yield:

: 179811-61-1
rac-2-amino-2-(3-fluorophenyl)ethanol

: 1196546-34-5
6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 °C

2: sodium hydride / tetrahydrofuran / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

4: potassium fluoride / dimethyl sulfoxide / 18 h / 180 °C

5: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 20 h / 150 °C / Inert atmosphere

With potassium fluoride; lithium aluminium tetrahydride; water; sodium hydride; sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 1196551-87-7
2-chloro-N-(1-(3-fluorophenyl)-2-hydroxyethyl)acetamide

: 1196546-34-5
6-(6-(3-(3-fluorophenyl)morpholino)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3: potassium fluoride / dimethyl sulfoxide / 18 h / 180 °C

4: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 20 h / 150 °C / Inert atmosphere

With potassium fluoride; lithium aluminium tetrahydride; water; sodium hydride; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;