(S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol

Base Information

Chemical Name:(S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol
CAS No.:325957-58-2
Molecular Formula:C₃₀H₅₂O₄SSi
Molecular Weight:536.892
Hs Code.:

Synonyms:(S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol

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Chemical Property of (S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol

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Technology Process of (S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol

There total 7 articles about (S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1-bromo-4-methyl-4-[(triethylsilyl)oxy]pentane

: 244241-61-0
(1S,3aS,4S,7aS)-(4-benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-acetic acid ethyl ester

: 2-[(1S,3aS,7aS)-4-Benzenesulfonyl-7a-methyl-4-(4-methyl-4-triethylsilanyloxy-pentyl)-octahydro-inden-1-yl]-ethanol

: 325957-58-2
(S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol

Guidance literature:: (1S,3aS,4S,7aS)-(4-benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-acetic acid ethyl ester; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

1-bromo-4-methyl-4-[(triethylsilyl)oxy]pentane; In tetrahydrofuran; at 25 ℃;

With diisobutylaluminium hydride; In dichloromethane; at -20 - 25 ℃;
DOI:10.1016/S0960-894X(00)00598-9

Reference yield:

: 66613-24-9
(phenylsulfanyl)methyl vinyl ketone

: 325957-58-2
(S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: (R)-(+)-phenylalanine; Et₃N; D-CSA / dimethylformamide / 25 - 55 °C

2.1: m-CPBA / CH₂Cl₂

3.1: LiAlH₄ / tetrahydrofuran / Heating

4.1: CrO₃; H₂SO₄ / acetone

5.1: 80 percent / NaH; HMPA / dimethylformamide / -20 - 25 °C

6.1: 97 percent / H₂ / Pd / ethanol

7.1: LDA; HMPA / tetrahydrofuran / -78 °C

7.2: tetrahydrofuran / 25 °C

7.3: 85 percent / DIBAL-H / CH₂Cl₂ / -20 - 25 °C

With chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; sulfuric acid; D-(R)-phenylalanine; (1S)-10-camphorsulfonic acid; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; palladium; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 1.1: Robinson annulation;
DOI:10.1016/S0960-894X(00)00598-9

Reference yield:

: 244241-69-8
(7aR)-7a-methyl-4-phenylsulfanyl-2,3,7,7a-tetrahydro-6H-indene-1,5-dione

: 325957-58-2
(S)-2-((1S,3aS,4S,7aS)-4-Benzenesulfonyl-7a-methyl-octahydro-inden-1-yl)-6-methyl-6-triethylsilanyloxy-heptan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: m-CPBA / CH₂Cl₂

2.1: LiAlH₄ / tetrahydrofuran / Heating

3.1: CrO₃; H₂SO₄ / acetone

4.1: 80 percent / NaH; HMPA / dimethylformamide / -20 - 25 °C

5.1: 97 percent / H₂ / Pd / ethanol

6.1: LDA; HMPA / tetrahydrofuran / -78 °C

6.2: tetrahydrofuran / 25 °C

6.3: 85 percent / DIBAL-H / CH₂Cl₂ / -20 - 25 °C

With chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; palladium; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(00)00598-9