[4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid

Base Information

• Chemical Name: [4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid
• CAS No.: 409344-61-2
• Molecular Formula: C₁₇H₁₈N₄O₅
• Molecular Weight: 358.354
• Mol file: 409344-61-2.mol

Synonyms:[4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid

Chemical Property of [4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid

There total 1 articles about [4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6-amino-3-butyl-5-(4-carboxymethyloxybenzyliden)aminouracil → [4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid (409344-61-2)

Guidance literature:

With thionyl chloride; for 1h; Heating;

DOI:10.1021/jm011049y

Reference yield: 42.0%

phenylmethyl 1-piperazinecarboxylate (31166-44-6) + [4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid (409344-61-2) → 4-{[4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetyl}-piperazine-1-carboxylic acid benzyl ester

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1021/jm011049y

Reference yield: 38.0%

4-ethylpiperazine (5308-25-8) + [4-(1-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid (409344-61-2) → 1-butyl-8-{4-[2-(4-ethyl-piperazin-1-yl)-2-oxo-ethoxy]-phenyl}-3,7-dihydro-purine-2,6-dione

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/jm011049y