EC 1.1.3.22

Base Information

• Chemical Name: EC 1.1.3.22
• CAS No.: 9002-17-9
• Molecular Formula: N/A
• Molecular Weight: 0
• Hs Code.: 35079090

Synonyms:E.C.1.1.3.22; E.C. 1.17.3.2; E.C. 1.2.3.2; Hypoxanthine oxidase;Hypoxanthine-xanthine oxidase; Schardinger enzyme; Xanthine oxidase; Xanthineoxidoreductase; Xanthine:xanthine oxidase

Chemical Property of EC 1.1.3.22

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

Xanthine Oxidase from bovine milk lyophilized powder, 0.4-1.0?units/mg protein ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: An enzyme that is closely related to aldehyde oxidase (EC 1.2.3.1). Both are metalloflavoproteins of about 300,000 daltons. They consist of two subunits of equal size and contain molybdenum, FAD, and iron (as Fe/S) in a ratio of 1:1:4 per subunit. These enzymes are widely distributed and catalyze a reaction in which the substrate is hydroxylated by an oxygen atom derived from water and electrons from the substrate are transferred to a variety of acceptors. These two enzymes have a broad overlapping substrate specificity including many purines, pyrimidines, and pteridines. However, xanthine, the best known substrate for xanthine oxidase, is not a substrate for aldehyde oxidase whereas the reverse is true for quaternary pyridinium compounds, such as N0 -methylnicotinamide. The role of oxygen as an electron acceptor with its production of hydrogen peroxide and the intermediate superoxide anion (both potential toxicants) may not be important in vivo since there is evidence that these enzymes are NAD-dependent dehydrogenases in vivo and become oxidases as a result of modification during purification. However, they are probably important in two types of detoxication. The first of these is the hydroxylation of exogenous aldehydes, purines, pyrimidines and other heterocyclic compounds, and the second involves the utilization of exogenous compounds as electron acceptors. Examples of the latter include the conversion of organic nitro compounds to hydroxyamino derivatives and the reduction of N-oxides to the free base.
• Uses: Xanthine Oxidase from bovine milk has been used:in the preparation of xanthine oxidase (XO) solution for 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO)-spin trapping assayin in?vitro XO assay for screening Vietnamese medicinal plants for XO inhibitory activityas a standard to determine XO activityas a standard to test the synergistic effect of docosahexaenoic acid (DHA) This enzyme is useful for enzymatic determination of inorganic phosphorus, 5′-nucleotidase and adenosine deaminase when coupled with Purine-nucleoside phosphorylase (PNP-301) and uricase (UAO-201, UAO-211).

Refernces

Behavior of some purine derivatives towards xanthine oxidase

10.1007/BF00712225

One study investigates the effect of kinetin on red pigmentation in detached wheat leaves, suggesting it promotes coloration similarly to sucrose, purines, and pyrimidines. Another experiment explores the inhibition of phosphorylase enzymes by 2,4-Dichlorphenoxyacetat (2,4-D) in rat skeletal muscle and liver tissues, indicating significant inhibition at specific concentrations. A third study examines DNA synthesis in the kidneys and intestines of hypophysectomized rats after partial hepatectomy, revealing increased DNA synthesis in the kidneys but decreased in the intestines. Another research focuses on the behavior of certain purine derivatives against xanthine oxidase, showing that various purine derivatives can serve as substrates for this enzyme, which is crucial for maintaining purine base balance in cells. Additionally, the article includes studies on the weight determination of cells from different types of pituitary adenomas using an interference microscope, revealing differences in cell weights related to their activity and chemical composition.

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