(2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

Base Information

Chemical Name:(2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal
CAS No.:144681-66-3
Molecular Formula:C₂₁H₃₆O₅Si
Molecular Weight:396.599
Hs Code.:

Synonyms:(2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

Suppliers and Price of (2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

There total 8 articles about (2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 410080-91-0
(3R,4R)-1-(3,4-dimethoxybenzyl)oxy-4-methyl-3-(tert-butyldimethylsilyl)oxy-5-hexene

: 144681-66-3
(2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

Guidance literature:: (3R,4R)-1-(3,4-dimethoxybenzyl)oxy-4-methyl-3-(tert-butyldimethylsilyl)oxy-5-hexene; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; at 20 ℃; for 7h;

With sodium periodate; In tetrahydrofuran; water; for 2h;
DOI:10.1139/v01-133

Reference yield:

: 144681-75-4
3-<(3,4-Dimethoxyphenyl)methoxy>propanal

: 144681-66-3
(2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuOK; n-BuLi; (-)-B-methoxydiisopinocampheylborane / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

1.2: BF₃*OEt₂ / tetrahydrofuran; hexane; diethyl ether / 4 h / -78 °C

1.3: 72 percent / NaBO₃*4H₂O; H₂O / tetrahydrofuran; hexane; diethyl ether

2.1: 94 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / -78 - 20 °C

3.1: OsO₄; N-methylmorpholine-N-oxide / H₂O; tetrahydrofuran / 7 h / 20 °C

3.2: 88 percent / NaIO₄ / tetrahydrofuran; H₂O / 2 h

With (-)-B-methoxydiisopinocamphenylborane; 2,6-dimethylpyridine; osmium(VIII) oxide; n-butyllithium; potassium tert-butylate; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;
DOI:10.1139/v01-133

Reference yield:

: 410080-90-9
(3R,4R)-1-(3,4-dimethoxybenzyl)oxy-4-methyl-5-hexen-3-ol

: 144681-66-3
(2S,3R)-5-(3,4-dimethoxybenzyl)oxy-2-methyl-3-(tert-butyldimethylsilyl)oxypentanal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / -78 - 20 °C

2.1: OsO₄; N-methylmorpholine-N-oxide / H₂O; tetrahydrofuran / 7 h / 20 °C

2.2: 88 percent / NaIO₄ / tetrahydrofuran; H₂O / 2 h

With 2,6-dimethylpyridine; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1139/v01-133