1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

Base Information

• Chemical Name: 1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide
• CAS No.: 552832-91-4
• Molecular Formula: C₂₅H₂₁F₂N₇O₃S
• Molecular Weight: 537.55

Synonyms:1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

Chemical Property of 1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

Chemical Property:

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Technology Process of 1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

There total 1 articles about 1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(2'-tert-butylaminosulfonyl-3-fluoro-[1,1']-biphen-4-yl)amine (209919-51-7) + ethyl 1-(3-cyano-4-fluorophenyl)-5-tetrazole carboxylate (218301-75-8) → 1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide (552832-91-4)

Guidance literature:

With trimethylaluminum; In dichloromethane;

DOI:10.1016/S0960-894X(02)00951-4

Reference yield:

1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide (552832-91-4) + acetone oxime (127-06-0) → 1-(3-amino-benzo[d]isoxazol-5-yl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

Guidance literature:

1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide; acetone oxime; With potassium tert-butylate;

With hydrogenchloride; In ethanol; Heating;

DOI:10.1016/S0960-894X(02)00951-4

Reference yield:

1-(3-cyano-4-fluoro-phenyl)-1H-tetrazole-5-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide (552832-91-4) → SR 374

Guidance literature:

Multi-step reaction with 2 steps

1.1: KO-tBu

1.2: HCl / ethanol / Heating

With potassium tert-butylate;

DOI:10.1016/S0960-894X(02)00951-4

upstream raw materials:

(2'-tert-butylaminosulfonyl-3-fluoro-[1,1']-biphen-4-yl)amine

ethyl 1-(3-cyano-4-fluorophenyl)-5-tetrazole carboxylate

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