(3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

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Chemical Name:(3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid
CAS No.:1423134-15-9
Molecular Formula:C₂₉H₄₄FN₃O₇
Molecular Weight:565.683
Hs Code.:

Synonyms:(3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

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Chemical Property of (3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

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Technology Process of (3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

There total 10 articles about (3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423134-78-4
tert-butyl 4-{3-[(3R)-3-{[(1S)-1-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

: 1423134-15-9
(3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Guidance literature:: tert-butyl 4-{3-[(3R)-3-{[(1S)-1-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate; With barium hydroxide octahydrate; In methanol; tert-butyl alcohol; at 20 ℃; for 1h;

With formic acid; In water; at 5 - 20 ℃; for 21h;

Reference yield:

: 1423134-70-6
tert-butyl {[3-(benzyloxy)phenyl](phenylsulfonyl)methyl}carbamate

: 1423134-15-9
(3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / water; toluene / 144 h / -20 - 0 °C

2.1: formic acid / 20 h / 0 - 5 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 °C

4.1: formic acid / 120 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 4 h / 60 °C

6.1: triethylamine / dichloromethane / 2 h

7.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h

8.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

9.1: barium hydroxide octahydrate / methanol; tert-butyl alcohol / 1 h / 20 °C

9.2: 21 h / 5 - 20 °C

With formic acid; barium hydroxide octahydrate; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1700-37-4
3-Benzyloxybenzaldehyde

: 1423134-15-9
(3S)-3-(3-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: formic acid / tetrahydrofuran; water / 96 h

2.1: caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / water; toluene / 144 h / -20 - 0 °C

3.1: formic acid / 20 h / 0 - 5 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 °C

5.1: formic acid / 120 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 4 h / 60 °C

7.1: triethylamine / dichloromethane / 2 h

8.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h

9.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

10.1: barium hydroxide octahydrate / methanol; tert-butyl alcohol / 1 h / 20 °C

10.2: 21 h / 5 - 20 °C

With formic acid; barium hydroxide octahydrate; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;