Technology Process of methyl 2-cyano-2-(4-cyanobenzyl)pent-4-enoate
There total 2 articles about methyl 2-cyano-2-(4-cyanobenzyl)pent-4-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
allyl methyl carbonate;
With
2-[2-(diphenylphosphino)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole; palladium diacetate;
In
tetrahydrofuran;
at 25 ℃;
Schlenk technique;
Inert atmosphere;
(E)-methyl 2-cyano-3-(4-cyanophenyl)acrylate;
With
diethoxymethylane; [(1,3-bis(2,4,6-trimethylphenyl)-imidazol-2-ylidene)Cu(dibenzoylmethanate)];
In
tetrahydrofuran;
at 25 ℃;
for 24h;
Schlenk technique;
Inert atmosphere;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 25 ℃;
for 0.0833333h;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/chem.201404015
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic acid; piperidine / methanol / 20 °C / Schlenk technique; Inert atmosphere
2.1: 2-[2-(diphenylphosphino)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole; palladium diacetate / tetrahydrofuran / 25 °C / Schlenk technique; Inert atmosphere
2.2: 24 h / 25 °C / Schlenk technique; Inert atmosphere
2.3: 0.08 h / 25 °C / Schlenk technique; Inert atmosphere
With
2-[2-(diphenylphosphino)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole; piperidine; palladium diacetate; acetic acid;
In
tetrahydrofuran; methanol;
DOI:10.1002/chem.201404015
