ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

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Chemical Name:ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
CAS No.:543745-07-9
Molecular Formula:C₂₁H₂₆N₄O₄
Molecular Weight:398.462
Hs Code.:

Synonyms:ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

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Chemical Property of ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

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Technology Process of ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

There total 14 articles about ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 543745-06-8
ethyl 6-(1-benzyl-4-piperidinyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

: 543745-07-9
ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2006.11.071

Reference yield:

: ethyl 1-(4-methoxyphenyl)-7-oxo-6-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

: 543745-07-9
ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; at 20 ℃; for 12h; under 2585.81 Torr;

Reference yield:

: N-(1-benzylpiperidin-4-yl)-5-bromopentanamide

: 543745-07-9
ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / tetrahydrofuran / 0.5 h / 0 °C

2: 85 percent / PCl₅ / CHCl₃ / 3 h / Heating

3: 86 percent / Heating

4: Et₃N / toluene / 85 °C

5: aq. HCl / CH₂Cl₂ / 4 h / 20 °C

6: 94 percent / H₂; HOAc / Pd/C / methanol / 3 h / 20 °C

With hydrogenchloride; phosphorus pentachloride; potassium tert-butylate; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; toluene;
DOI:10.1016/j.bmcl.2006.11.071