(E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide

Base Information

Chemical Name:(E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide
CAS No.:610768-49-5
Molecular Formula:C₂₄H₂₆N₄O₃S
Molecular Weight:450.561
Hs Code.:

Synonyms:(E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide

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Chemical Property of (E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide

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Technology Process of (E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide

There total 13 articles about (E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 610768-37-1
N-benzyl-N-[(2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]amine

: 610768-49-5
(E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol0352862

Reference yield: 82.0%

: 102-92-1,17082-09-6
cinnamoyl chloride

: 610768-37-1
N-benzyl-N-[(2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]amine

: 610768-49-5
(E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00657b

Reference yield:

: 610768-34-8
4-[(1E)-3-chloroprop-1-enyl]-1-dimethylsulfamoyl-1H-imidazole

: 610768-49-5
(E,E)-4-[3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl]-N-benzyl-3-phenyl-2-propenamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / dimethylformamide / 20 °C

2.1: 90 percent / hydrazine monohydrate / ethanol / 3 h / Heating

3.1: ethanol / 2 h / 20 °C

3.2: 92 percent / NaBH₄ / ethanol / 20 °C

4.1: 82 percent / NaHCO₃ / CH₂Cl₂ / 0 - 20 °C

With sodium hydrogencarbonate; hydrazine hydrate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0352862