N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride

Base Information

• Chemical Name: N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride
• CAS No.: 512822-19-4
• Molecular Formula: C₁₄H₁₄F₆N₂O₃S*ClH
• Molecular Weight: 440.794
• Mol file: 512822-19-4.mol

Synonyms:N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride

Chemical Property of N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride

There total 1 articles about N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,5-bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester (512818-39-2) → N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride (512822-19-4)

Guidance literature:

With hydrogenchloride; methanol; In diethyl ether; dichloromethane; at 20 ℃; for 16h;

Reference yield:

N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide hydrochloride (512822-19-4) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → N-[1-(2-nitro-phenyl)-piperidine-4-carbonyl]-3,5-bis-trifluoromethyl-benzenesulfonamide (512819-11-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80 ℃; for 18h;

upstream raw materials:

4-(3,5-bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

N-[1-(2-nitro-phenyl)-piperidine-4-carbonyl]-3,5-bis-trifluoromethyl-benzenesulfonamide