4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

Base Information

Chemical Name:4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide
CAS No.:1365244-33-2
Molecular Formula:C₁₈H₁₇BrN₄O₃S
Molecular Weight:449.328
Hs Code.:

Synonyms:4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

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Chemical Property of 4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

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Technology Process of 4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

There total 9 articles about 4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365244-30-9
4-[6-bromo-8-(methylsulfanyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

: 1365244-33-2
4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

: 4-[6-bromo-8-(methylsulfinyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

Guidance literature:: With Oxone; In N,N-dimethyl-formamide; at 20 ℃; Overall yield = 60 %; Overall yield = 8.6 g; Inert atmosphere;

Reference yield:

: 1365243-73-7
6,8-dibromo-3-iodoimidazo[1,2-b]pyridazine

: 1365244-33-2
4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

: 4-[6-bromo-8-(methylsulfinyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane / 122 h / 60 - 80 °C / Inert atmosphere

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 12 h / 60 °C / Inert atmosphere

3: Oxone / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Oxone; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1206487-36-6
6,8-dibromoimidazo[1,2-b]pyridazine

: 1365244-33-2
4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

: 4-[6-bromo-8-(methylsulfinyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

2: 1,4-dioxane / 122 h / 60 - 80 °C / Inert atmosphere

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 12 h / 60 °C / Inert atmosphere

4: Oxone / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Oxone; N-iodo-succinimide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;